Louise of Savoy
Louise of Savoy was a French noblewoman, Duchess suo jure of Auvergne and Bourbon, Duchess of Nemours, and the mother of King Francis I of France. She was politically active and served as the Regent of France in 1515, in 15251526 and in 1529.
Louise of Savoy was born at PontdAin, the eldest daughter of Philip II, Duke of Savoy and his first wife, Margaret of Bourbon. Her brother, Philibert II, Duke of Savoy, succeeded her father as ruler of the duchy and head of the House of Savoy. He was, in turn, succeeded by their halfbrother Charles III, Duke of Savoy.
Source: Wikipedia