Margherita Gonzaga, Duchess of Lorraine
Margherita Gonzaga was Duchess of Lorraine from 1606 until her husbands death in 1624.
She was born in Mantua, the eldest daughter of Vincenzo I Gonzaga and Eleonora de Medici she was also a sister of Francesco IV Gonzaga, Ferdinando I Gonzaga, Vincenzo II Gonzaga and Eleonora Gonzaga. Her brothers all succeeded their father as Duke of Mantua and Eleonora became Holy Roman Empress by her marriage to Ferdinand II, Holy Roman Emperor.
Source: Wikipedia