Maria Manuela, Princess of Portugal

Dona Maria Manuela was the eldest daughter and second child of King John III of Portugal and his wife Catherine of Austria. She was Princess of Asturias as the first wife of the future Philip II of Spain, and Princess of Portugal as heir presumptive to the Portuguese throne between 1527 and 1535.

Maria was born in Coimbra onOctober 1527 and was one of the few children of John III to survive childhood. She married her cousin Philip onNovember 1543 at Salamanca. She gave birth to their son Don Carlos onJuly 1545, but died four days later due to a haemorrhage in Valladolid.

Source: Wikipedia