Eleanor of Toledo

Eleanor of Toledo , born Doa Leonor lvarez de Toledo y Osorio, was a Spanish noblewoman who was Duchess of Florence from 1539. She is credited with being the first modern first lady, or consort. She served as regent of Florence during the absence of her spouse.

Eleanor was born in Alba de Tormes, Salamanca as the second daughter of the Viceroy of Naples, Don Pedro lvarez de Toledo, Marquis of Villafranca and Maria Osorio, 2nd Marquise of Villafranca. Her father was the second son of Fadrique lvarez de Toledo, 2nd Duke of Alba and therefore, the 3rd Duke of Alba was his eldest brother.

Source: Wikipedia