St. Louis Blues is a 1958 American film broadly based on the life of W. C. Handy. It starred jazz and blues greats Nat King Cole, Pearl Bailey, Cab Calloway, Ella Fitzgerald, Eartha Kitt, and Barney Bigard, as well as gospel singer Mahalia Jackson and actress Ruby Dee. The films soundtrack used over ten of Handys songs including the title song.
Source: Wikipedia